|
KMID : 0359919920110020153
|
|
Korean Journal of Nephrology
1992 Volume.11 No. 2 p.153 ~ p.158
|
|
|
Serial Changes of Serum Level of Soluble Interleukin-2 Receptor and Interleukin-6 after Kidney Transplantation
|
|
채동완
최우창/전노원/이영천/노정우/김순일/조현찬
|
|
|
Abstract
|
|
|
Various cytokines and cytokine receptors are known to play the important role in immune response in renal transplantation. We attempted to observe the influences of preoperative immunosuppression, operation and accompanying hallange of
transplantation
antigen, recovery of renal function on the serum soluble interleukin 2 receptor (sIL2R) and interleukin-6 (IL6) by measuring serun concentration of sIL2R and IL6 at basal state, after 2 days preoperative immunosuppression, postoper ative 1 day, 3
days,
7 days and 21 days and the following results were obtained.
1) Basal sIL2R level was 222.66+59.49 pmol/L and was not affected by preoperative immunosuppression. Following transplantation sIL2R level decreased to 155.16+61.95 pmol/L at postoperative 1 day (p=0.041) and showed tendancy to decrease further
at
postoperative 3 days (126.63+85.49 pmol/L p=0.053) and remained low until postoperative 21 days.
2) Basal IL 6 level was 1.17+0.25 pg/ml and was not affected by preoperative immunosuppression. Following transplantation IL6 level increased to 1.43+0.30 pg/ml at postoperative 1 days (p=0.002) and showed no signigicant changes thereafter until
postoperative 21 days.
3) While only 1 patient developed acute rejection in 6 patients whose sIL2R level decreased after preoperative immunosuppression, 4 patients develpoed acute rejection in 5 patients whose sIL2R level did not decreased after preoperative
immunosuppression (p=0.067) and this finding was not related to HLA or blood type compatibilities.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|